Jtdylktuy

As DevSolar mentioned in his comment, this really depends on how you define 'major', but here are several case of migrants moving from the New to the Old World.

From the Caribbean to Europe

According the (British) National Archives, between 1948 and 1970,

nearly half a million people left their homes in the West Indies to
live in Britain

There were also significant migrations to France and the Netherlands. According to Migration from the Colonies to Western Europe since 1800

In 1975, more than 100,000 migrants from the Caribbean were living in
metropolitan France.

Also, around 180,000 Surinamese immigrants arrived in the Netherlands, mostly between 1975 and 1980.

From North America to West Africa

Another, much smaller but nonetheless historically significant migration from New to Old led to the founding of Liberia. This involved the migration of around 13,000 African Americans during the nineteenth century.

Yes, there has been.

As this infographic shows, there has been a back-migration of the DNA haplogroups C1a and A2a from North America (well, Beringia...) back into Asia.

The infographic is sourced as Tamm E, Kivisild T, Reidla M, Metspalu M, Smith DG, et al. (2007) Beringian Standstill and Spread of Native American Founders. PLoS ONE 2(9): e829. doi:10.1371/journal.pone.0000829.

Other (later) back-migrations might exist; I understood that your question would be answered with one "yes" already and stopped searching at this point.

In addition to Lars Bosteen's answer about modern migration, several hundred thousand South American people have migrated to Spain in the last decades, and Brazilians have became the largest group of foreigners in Portugal. Other European countries with fewer ties and common background with America seem to host smaller populations.

Furthermore, if the "native-americans" tag in the question means that the OP is more interested in migration of descendants of native Americans than migration of Americans of European descent, the migration of Ecuadorians to Spain may qualify as the largest trans-Atlantic migration of people of native American or mixed descent.

Horses evolved on the North American landmass, emigrated across the Bering land bridge, then went extinct in the Americas.

The question is tagged native-americans and alaska though uses the term new-world, which is a purely Eurocentric perspective. Also, it is not immediately clear what "Old World" means in regards to locales other than Europe proper; or if the question is focused on actual Native Americans or individuals and institutions who invaded Turtle Island and now claim the geography as their own by right of conquest. It must also be noted here that Native American prisoners of war (commonly referred to as "slaves") were shipped to Europe from the "New World" prior to the abolition of "slavery" in the "New World"; which is not migration, but rather a tactic of war to seize and control the land of the original people in the "New World"; i.e.g., see Colonists shipped Native Americans abroad as slaves by Gillian Kiley-Brown

While natives had been forced into slavery and servitude as early as
1636, it was not until King Philip’s War that natives were enslaved in
large numbers, Fisher writes in the study. The 1675 to 1676 war pitted
Native American leader King Philip, also known as Metacom, and his
allies against the English colonial settlers.

During the war, New England colonies routinely shipped Native
Americans as slaves to Barbados, Bermuda, Jamaica, the Azores, Spain,
and Tangier in North Africa, Fisher says.

Have inquired into why people of European descent do not migrate or "caravan" back to Europe en masse. The conclusion that have drawn is that the conditions which precipitated mass departure from Europe between 1500 and 1900 still exist; and people who claim to be of European descent in the "New World" actually have little interest in returning to the lands and culture they claim by virtue of purported ancestral lineage or "origin", as the evidence supports.

People who claim to be "Jew" do more frequently migrate to Isreal which could be considered "Old World", unless, again by the term "Old World" the question refers to only regions of Europe proper, or euphemistically; that is, the question does not present definitive nations or geographic locations specifying precisely where "Old World" supposedly begins or concludes, certainly not from the perspective of individuals who do not self-identify as "European"; or if such notions of "Old World" exist primarily as nostalgia in individuals' minds who claim to be of European descent, as an expression of Eurocentrism, negating the fact that "Old World" could also be applicable to "Africa" or "Australia", et al.; as the designation "Old World" is not commonly found on any map.

In any event, see Aliyah

(US: /ˌæliˈɑː/, UK: /ˌɑː-/; Hebrew: עֲלִיָּה‬ aliyah, "ascent") is
the immigration of Jews from the diaspora to the Land of Israel (Eretz
Israel in Hebrew). Also defined as "the act of going up"—that is,
towards Jerusalem—"making Aliyah" by moving to the Land of Israel is
one of the most basic tenets of Zionism.

Aliyah from Latin America

In the 1999–2002 Argentine political and economic crisis that caused a
run on the banks, wiped out billions of dollars in deposits and
decimated Argentina's middle class, most of the country's estimated
200,000 Jews were directly affected. Some 4,400 chose to start over
and move to Israel, where they saw opportunity.

More than 10,000 Argentine Jews immigrated to Israel since 2000,
joining the thousands of previous Argentine immigrants already there.
The crisis in Argentina also affected its neighbour country Uruguay,
from which about half of its 40,000-strong Jewish community left,
mainly to Israel, in the same period. During 2002 and 2003 the Jewish
Agency for Israel launched an intensive public campaign to promote
aliyah from the region, and offered additional economic aid for
immigrants from Argentina. Although the economy of Argentina improved,
and some who had immigrated to Israel from Argentina moved back
following South American country's economic growth from 2003 onwards,
Argentine Jews continue to immigrate to Israel, albeit in smaller
numbers than before. The Argentine community in Israel is about
50,000-70,000 people, the largest Latin American group in the country.

There has also been immigration from other Latin American countries
that have experienced crises, though they have come in smaller numbers
and are not eligible for the same economic benefits as immigrants to
Israel from Argentina.

In Venezuela, growing antisemitism in the country, including
antisemitic violence, caused an increasing number of Jews to move to
Israel during the 2000s. For the first time in Venezuelan history,
Jews began leaving for Israel in the hundreds. By November 2010, more
than half of Venezuela's 20,000-strong Jewish community had left the
country.^{51, 52}

Aliyah from North America

More than 200,000 North American immigrants live in Israel. There has
been a steady flow of immigration from North America since Israel’s
inception in 1948.^{82, 83}

Several thousand American Jews moved to Mandate Palestine before the
State of Israel was established. From Israel's establishment in 1948
to the Six-Day War in 1967, aliyah from the United States and Canada
was minimal. In 1959, a former President of the Association of
Americans and Canadians in Israel estimated that out of the 35,000
American and Canadian Jews who had made aliyah, only 6,000
remained.⁸⁴

Following the Six-Day War in 1967, and the subsequent euphoria among
world Jewry, significant numbers arrived in the late 1960s and 1970s,
whereas it had been a mere trickle before. Between 1967 and 1973,
60,000 North American Jews immigrated to Israel. However, many of them
later returned to their original countries. An estimated 58% of
American Jews who immigrated to Israel between 1961 and 1972 ended up
returning to the United States.^{85, 86}

Like Western European immigrants, North Americans tend to immigrate to
Israel more for religious, ideological, and political purposes, and
not financial or security ones.⁸⁷ Many immigrants
began arriving in Israel after the First and Second Intifada, with a
total of 3,052 arriving in 2005 — the highest number since
1983.⁸⁸

Nefesh B'Nefesh, founded in 2002 by Rabbi Yehoshua Fass and Tony
Gelbart, works to encourage Aliyah from North America and the UK by
providing financial assistance, employment services and streamlined
governmental procedures. Nefesh B’Nefesh works in cooperation with the
Jewish Agency and the Israeli Government in increasing the numbers of
North American and British immigrants.

Following the Global Financial Crisis in the late 2000s, American
Jewish immigration to Israel rose. This wave of immigration was
triggered by Israel's lower unemployment rate, combined with financial
incentives offered to new Jewish immigrants. In 2009, aliyah was at
its highest in 36 years, with 3,324 North American Jews making
aliyah.⁸⁹

As to "why": Unforced migration is opportunistic. Moving somewhere else is risky and requires effort so that a degree of suffering at the current location or at least a substantial promise of improvement at the target location is needed to start a migration.

Prominent examples are the Irish famine or the Californian gold rush. More generally, the migration of Europeans which was not the direct result of religious prosecution and famines was motivated by perceived opportunities abroad which were not present at home.

Some of the opportunities were social — the feudalistic, strictly organized societies of the 17th and 18th century were severely regulating the lives of the common people while the founding document of the United States explicitly stated that "Life, Liberty and the pursuit of Happiness" were "inherent and inalienable rights" of man.

More direct, materialistic opportunities were present in the abundance of natural resources, mostly land, which is attractive to members of pre-industrial societies in full possession of their abilities (chiefly young, adventurous, energetic people).¹

With this analysis we can predict that the direction of migration may reverse when opportunities in the Americas appear much worse than in Europe. An aging and shrinking European population may generate attractive job and housing opportunities, and bad governance in the Americas (including the U.S., if you look at it) may decrease opportunities there. As others have remarked such a trend can already be observed.